Response to nitrosative stress

Across TCGA cell cohorts, RNA activity of the Response to nitrosative stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VWA1, INPPL1, and MAST4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VWA1 grouped by Response to nitrosative stress-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWA1 →	-0.978	-1.022	.002	.003	3	3
LARGE_INTESTINE	INPPL1 →	-0.927	-0.801	.009	.009	3	3
LARGE_INTESTINE	MAST4 →	-0.830	-0.670	.005	.005	3	3
SOFT_TISSUE	CDCA5 →	+0.638	+1.474	.003	.001	3	3
LUNG_NSCLC_LUSC	ATP5PB →	+0.576	+1.453	.002	<.001	3	3
SKIN	G6PC3 →	-0.475	-0.940	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VWA1 by Response to nitrosative stress activity — BLOOD_Leukemia

Explore this box plot interactively →