Response to nitrosative stress

Across TCGA cell cohorts, RNA activity of the Response to nitrosative stress pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCLM, DIPK1A, and PRKACB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nitrosative stress activity versus GCLM in LIVER (Pearson r = 0.92).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GCLM →	+2.436	+1.881	.008	<.001	3	8
CNS	DIPK1A →	+1.586	+1.298	.004	.007	3	5
BLOOD_Leukemia	PRKACB →	+1.210	+0.854	.002	.001	3	5
LUNG_NSCLC_LUAD	VEGFD →	+0.666	+1.187	.009	<.001	3	4
BREAST	LRRC8D →	+1.404	+1.630	.002	<.001	3	4
OESOPHAGUS	PDZD7 →	-1.680	-2.049	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051409 vs GCLM — LIVER

Explore this scatter interactively →