Neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHS, EBP, and XIST, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron apoptotic process activity versus GAPDHS in COAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDHS →	-0.068	-0.287	.007	.007	3	1
COAD	EBP →	+0.523	+0.182	.001	.005	2	1
COAD	XIST →	+2.675	+0.173	.009	.008	2	1
COAD	WDR45 →	+0.335	+0.204	.006	.002	1	1
COAD	KRT18P63 →	-0.294	-0.185	.009	.008	1	1
COAD	TSIX →	+0.078	+0.243	.008	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051402 vs GAPDHS — COAD

Explore this scatter interactively →