Neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA10, MOB3B, and SOCS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron apoptotic process activity versus NAA10 in URINARY_TRACT (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NAA10 →	-0.975	-0.297	.006	.006	3	5
URINARY_TRACT	MOB3B →	+2.173	+0.218	.003	.007	3	4
URINARY_TRACT	SOCS2 →	-3.940	-0.249	<.001	.009	3	4
SKIN	ARPC5 →	-0.485	-0.141	.001	.005	3	4
STOMACH	PA2G4 →	-0.985	-0.180	<.001	<.001	3	4
SKIN	AIFM3 →	+0.770	+0.161	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051402 vs NAA10 — URINARY_TRACT

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