Negative regulation of oxidoreductase activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPOCK2, GZMK, and LY9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of oxidoreductase activity activity versus SPOCK2 in CCRCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPOCK2 →	+0.530	+0.165	<.001	<.001	3	5
HNSC	GZMK →	+0.812	+0.164	.003	.006	3	5
LSCC	LY9 →	+0.492	+0.115	.008	.001	3	5
LSCC	APOL3 →	+0.476	+0.095	.002	.001	3	5
LSCC	CD27 →	+0.571	+0.125	.002	.006	3	5
BRCA	GZMA →	+0.992	+0.128	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051354 vs SPOCK2 — CCRCC

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