Negative regulation of oxidoreductase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidoreductase activity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC23A, MYO1D, and RILPL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC23A grouped by Negative regulation of oxidoreductase activity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SEC23A →	-0.700	-1.088	.003	.001	3	4
LUNG_SCLC	MYO1D →	+2.985	+1.762	<.001	<.001	3	4
LUNG_SCLC	RILPL2 →	-1.165	-1.682	.008	<.001	3	4
LUNG_SCLC	NECAP2 →	-0.629	-1.344	<.001	.002	3	4
KIDNEY	ENPP2 →	-0.721	-1.326	.002	.006	2	4
OVARY	RLN2 →	+1.238	+1.108	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC23A by Negative regulation of oxidoreductase activity activity — CNS

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