Negative regulation of hydrolase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of hydrolase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKIG, ZNF622, and PLIN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hydrolase activity activity versus PKIG in BLOOD_Lymphoma (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PKIG →	-1.292	-0.187	.002	.003	3	4
LUNG_NSCLC_LUAD	ZNF622 →	-0.607	-0.469	<.001	.003	3	3
OVARY	PLIN3 →	-0.960	-0.898	.008	.006	3	3
OVARY	NRG1 →	-2.255	-1.033	.004	.001	3	3
OVARY	VXN →	-0.371	-0.803	<.001	.007	3	3
OESOPHAGUS	MUC12 →	-1.131	-0.638	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051346 vs PKIG — BLOOD_Lymphoma

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