Meiotic cell cycle

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB16, NDRG3, and G6PC3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle activity versus ASB16 in BRCA (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASB16 →	+2.128	+2.216	.004	.002	3	3
COAD	NDRG3 →	+0.420	+0.679	.002	<.001	3	2
COAD	G6PC3 →	+0.333	+0.764	.006	<.001	3	2
BRCA	CSNK1D →	+1.393	+2.216	<.001	.002	3	2
BRCA	ZNF687 →	+1.741	+2.216	<.001	.002	3	2
BRCA	SETD1A →	+1.741	+2.216	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051321 vs ASB16 — BRCA

Explore this scatter interactively →