Meiotic cell cycle

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM2, CEP131, and CAPN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle activity versus PRDM2 in SOFT_TISSUE (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRDM2 →	+1.216	+0.298	.003	<.001	3	5
BLOOD_Leukemia	CEP131 →	+0.576	+0.141	.009	.001	2	6
BLOOD_Leukemia	CAPN2 →	-1.548	-0.096	.003	<.001	3	5
SKIN	RAD54L2 →	+0.874	+0.140	.002	.003	3	5
BLOOD_Leukemia	HCFC1 →	+0.757	+0.103	<.001	.001	3	5
LUNG_NSCLC_LUSC	CALM2 →	+0.953	+0.177	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051321 vs PRDM2 — SOFT_TISSUE

Explore this scatter interactively →