Attachment of mitotic spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFR2, LIN9, and KIF23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of mitotic spindle microtubules to kinetochore activity versus MTFR2 in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTFR2 →	+0.669	+0.637	<.001	<.001	3	7
BRCA	LIN9 →	+0.559	+0.663	.002	<.001	3	7
GBM	KIF23 →	+0.909	+0.571	<.001	.001	3	7
LSCC	HELLS →	+0.988	+0.595	<.001	<.001	3	6
LUAD	UCK2 →	+0.728	+0.539	<.001	.002	3	6
LSCC	CENPI →	+0.830	+0.649	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051315 vs MTFR2 — BRCA

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