Attachment of mitotic spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INCENP, KAT5, and AURKB, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INCENP grouped by Attachment of mitotic spindle microtubules to kinetochore-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	INCENP →	-0.380	-0.247	<.001	.002	3	8
SOFT_TISSUE	KAT5 →	-0.387	-0.231	.003	.002	3	7
STOMACH	AURKB →	-0.318	-0.262	<.001	<.001	3	7
PANCREAS	BIRC5 →	-0.546	-0.166	.009	.009	2	7
SOFT_TISSUE	PIK3C2G →	+0.195	+0.209	<.001	<.001	3	5
SOFT_TISSUE	ESCO2 →	+0.284	+0.248	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INCENP by Attachment of mitotic spindle microtubules to kinetochore activity — PANCREAS

Explore this box plot interactively →