Attachment of mitotic spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS1, ZC3HC1, and RBBP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of mitotic spindle microtubules to kinetochore activity versus OAS1 in LUNG_NSCLC_LUAD (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OAS1 →	-1.644	-0.786	.004	<.001	3	5
PANCREAS	ZC3HC1 →	+0.604	+1.183	.009	.006	3	5
OVARY	RBBP5 →	+0.760	+0.726	<.001	.009	3	5
OVARY	NAF1 →	+0.596	+0.805	.003	.004	3	5
OESOPHAGUS	PRR3 →	+1.262	+1.115	.008	.001	3	5
LUNG_NSCLC_LUAD	SMC3 →	+0.665	+0.801	.009	.008	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051315 vs OAS1 — LUNG_NSCLC_LUAD

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