Metaphase chromosome alignment

Across TCGA patient cohorts, RNA activity of the Metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MELK, ASPM, and KIF11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Metaphase chromosome alignment activity versus MELK in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MELK →	+1.112	+0.296	<.001	.001	3	6
LSCC	ASPM →	+2.112	+0.651	<.001	<.001	3	6
BRCA	KIF11 →	+1.281	+0.440	<.001	.001	3	6
LSCC	FAM72D →	+1.236	+0.652	.002	<.001	3	5
UCEC	DNA2 →	+1.092	+0.342	.008	.001	2	6
BRCA	CDCA5 →	+1.725	+0.576	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051310 vs MELK — BRCA

Explore this scatter interactively →