Metaphase chromosome alignment

Across TCGA cell cohorts, RNA activity of the Metaphase chromosome alignment pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SS18, ZMYM4, and PPP1R8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SS18 grouped by Metaphase chromosome alignment-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SS18 →	-0.741	-0.232	<.001	<.001	3	5
OVARY	ZMYM4 →	-0.833	-0.239	<.001	.001	3	5
OVARY	PPP1R8 →	-0.553	-0.192	<.001	.002	3	5
BLOOD_Leukemia	RNMT →	+0.504	+0.219	.003	.008	3	5
SOFT_TISSUE	EXTL2 →	-0.580	-0.221	.006	.002	3	5
OVARY	SOX12 →	-1.228	-0.172	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SS18 by Metaphase chromosome alignment activity — PANCREAS

Explore this box plot interactively →