Meiotic chromosome separation

Across TCGA patient cohorts, RNA activity of the Meiotic chromosome separation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, SGO1, and BLM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome separation activity versus GINS1 in BRCA (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GINS1 →	+0.705	+0.273	<.001	.001	3	6
BRCA	SGO1 →	+0.678	+0.365	.001	<.001	3	6
LSCC	BLM →	+0.730	+0.282	<.001	.002	3	6
UCEC	GTSE1 →	+0.648	+0.290	<.001	<.001	3	6
LSCC	MCM4 →	+0.986	+0.465	<.001	.001	3	5
LSCC	EZH2 →	+0.894	+0.406	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051307 vs GINS1 — BRCA

Explore this scatter interactively →