Meiotic chromosome separation

Across TCGA cell cohorts, RNA activity of the Meiotic chromosome separation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRERF1, ELF1, and SCN9A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRERF1 grouped by Meiotic chromosome separation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRERF1 →	+0.450	+0.255	.002	.003	3	5
LARGE_INTESTINE	ELF1 →	-0.220	-0.127	.008	.002	3	4
UPPER_AERODIGESTIVE_TRACT	SCN9A →	+0.246	+0.224	.003	.002	2	5
OVARY	PTRH1 →	+0.213	+0.177	<.001	<.001	3	4
OVARY	PTTG2 →	-0.175	-0.160	.002	.002	3	4
BLOOD_Myeloma	TRIM51 →	+0.294	+0.192	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRERF1 by Meiotic chromosome separation activity — SOFT_TISSUE

Explore this box plot interactively →