Regulation of cell division

Across TCGA patient cohorts, RNA activity of the Regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERK, KCNMB1, and ID4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell division activity versus CERK in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CERK →	+0.553	+0.351	.001	.007	3	2
COAD	KCNMB1 →	+0.744	+0.398	.003	.002	3	2
COAD	ID4 →	+1.059	+0.509	<.001	.004	3	2
COAD	SMIM10L2A →	+0.218	+0.262	.007	.005	3	2
COAD	S1PR3 →	+0.541	+0.358	.003	.005	3	2
BRCA	MRAP2 →	-1.486	-0.332	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051302 vs CERK — COAD

Explore this scatter interactively →