Regulation of cell division

Across TCGA cell cohorts, RNA activity of the Regulation of cell division pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, NUDT1, and OR5T2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Regulation of cell division-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BCL2L1 →	-0.738	-0.195	<.001	.001	3	7
LUNG_SCLC	NUDT1 →	-0.226	-0.157	<.001	<.001	3	5
SKIN	OR5T2 →	+0.209	+0.203	.009	.001	3	5
UPPER_AERODIGESTIVE_TRACT	MAP4K4 →	+0.369	+0.219	.002	.001	3	5
BLOOD_Lymphoma	SFPQ →	-0.505	-0.146	.006	.001	3	4
BLOOD_Lymphoma	STARD13 →	+0.311	+0.149	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Regulation of cell division activity — LUNG_SCLC

Explore this box plot interactively →