Regulation of cell division

Across TCGA cell cohorts, RNA activity of the Regulation of cell division pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL6B, ENO2, and MBD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell division activity versus MYL6B in STOMACH (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MYL6B →	+1.222	+0.202	.002	<.001	3	6
LUNG_SCLC	ENO2 →	+1.893	+0.153	.004	.007	3	6
LIVER	MBD3 →	+0.907	+0.170	.002	<.001	3	6
STOMACH	ELMO3 →	-2.739	-0.259	.003	<.001	3	5
STOMACH	ARL3 →	+0.896	+0.198	.006	<.001	3	5
STOMACH	USP43 →	-1.956	-0.240	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051302 vs MYL6B — STOMACH

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