Centrosome separation

Across TCGA patient cohorts, RNA activity of the Centrosome separation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RRM2, and CDC20_T70, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome separation activity versus RFC2 in LSCC (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC2 →	+0.367	+0.073	<.001	<.001	3	10
LUAD	RRM2 →	+0.793	+0.133	<.001	<.001	3	10
LUAD	CDC20_T70 →	+1.197	+0.135	<.001	<.001	3	10
LUAD	HAT1 →	+0.403	+0.081	<.001	<.001	3	10
GBM	MCM6 →	+0.787	+0.121	<.001	<.001	3	10
LUAD	MKI67 →	+0.758	+0.119	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051299 vs RFC2 — LSCC

Explore this scatter interactively →