Centrosome separation

Across TCGA cell cohorts, RNA activity of the Centrosome separation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RER1, POP7, and PRR13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome separation activity versus RER1 in SKIN (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RER1 →	-0.655	-1.157	<.001	<.001	3	5
STOMACH	POP7 →	-1.070	-1.171	.009	<.001	3	4
OESOPHAGUS	PRR13 →	-0.799	-1.615	.008	<.001	3	4
OESOPHAGUS	RTF2 →	-0.895	-1.163	.002	.005	3	4
OESOPHAGUS	RNF114 →	-1.104	-1.296	<.001	<.001	3	4
OESOPHAGUS	SPATA2 →	-0.995	-1.619	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051299 vs RER1 — SKIN

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