Centrosome duplication

Across TCGA patient cohorts, RNA activity of the Centrosome duplication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF1, RGS2, and EMP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome duplication activity versus FGF1 in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGF1 →	-0.777	-0.770	.004	<.001	2	5
BRCA	RGS2 →	-1.158	-0.591	<.001	.007	3	4
BRCA	EMP1 →	-0.634	-0.567	.001	.004	3	4
BRCA	KLF9 →	-0.836	-0.778	<.001	<.001	3	4
BRCA	GALNT15 →	-0.711	-0.624	.009	.006	3	4
BRCA	TMEM119 →	-0.824	-0.655	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051298 vs FGF1 — BRCA

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