Centrosome duplication

Across TCGA patient cohorts, RNA activity of the Centrosome duplication pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC4A2_S113, YY1AP1_S724, and SRRM2_T2104, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome duplication activity versus SLC4A2_S113 in UCEC (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC4A2_S113 →	-0.854	-0.884	<.001	<.001	3	3
GBM	YY1AP1_S724 →	+0.363	+0.622	<.001	<.001	3	3
LSCC	SRRM2_T2104 →	+0.390	+0.737	<.001	<.001	3	3
BRCA	SVIL_S467 →	-0.539	-0.800	.002	<.001	3	3
GBM	BUB1B_S543 →	+0.683	+0.585	.001	.003	3	3
OV	AKAP12_T1760 →	-1.123	-0.933	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051298 vs SLC4A2_S113 — UCEC

Explore this scatter interactively →