Centrosome duplication

Across TCGA cell cohorts, RNA activity of the Centrosome duplication pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAXBP1, RNF115, and FOXD4L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAXBP1 grouped by Centrosome duplication-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PAXBP1 →	+1.308	+0.178	<.001	.001	3	5
BREAST	RNF115 →	+0.569	+0.149	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FOXD4L1 →	+0.122	+0.140	.005	.001	3	4
LUNG_SCLC	ILKAP →	+0.544	+0.161	.004	.004	3	4
LUNG_SCLC	POGZ →	+0.896	+0.211	.001	<.001	3	4
LUNG_SCLC	ZNF75D →	+0.751	+0.151	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAXBP1 by Centrosome duplication activity — LUNG_SCLC

Explore this box plot interactively →