Centrosome duplication

Across TCGA cell cohorts, RNA activity of the Centrosome duplication pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGK, INAVA, and CDK17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centrosome duplication activity versus AGK in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AGK →	+0.454	+1.412	.002	<.001	3	5
OVARY	INAVA →	-2.258	-1.087	<.001	<.001	3	5
BLOOD_Leukemia	CDK17 →	+0.627	+0.345	.005	.007	3	4
BLOOD_Leukemia	TBPL1 →	+0.748	+0.389	.003	.002	3	4
STOMACH	TTL →	+0.967	+1.094	.008	.001	2	5
OVARY	SCARA3 →	-2.644	-1.101	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051298 vs AGK — LIVER

Explore this scatter interactively →