Establishment of meiotic spindle localization

Across TCGA patient cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPIRE1, IMPA2, and TRMT1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of meiotic spindle localization activity versus SPIRE1 in HNSC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPIRE1 →	+0.571	+0.128	<.001	<.001	3	6
CCRCC	IMPA2 →	+0.442	+0.073	.009	.002	2	6
CCRCC	TRMT1L →	-0.213	-0.086	<.001	<.001	3	5
UCEC	HSPD1 →	+0.373	+0.074	<.001	.001	2	5
UCEC	PHLDB1_S404 →	-0.524	-0.079	<.001	.002	3	4
PDAC	TPI1 →	+0.140	+0.046	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051295 vs SPIRE1 — HNSC

Explore this scatter interactively →