Establishment of meiotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPECC1L, PRPS2, and USF2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of meiotic spindle localization activity versus SPECC1L in LUNG_SCLC (Pearson r = -0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SPECC1L →	-0.856	-0.505	.001	<.001	3	1
LUNG_SCLC	PRPS2 →	-1.388	-0.505	.001	<.001	3	1
LUNG_SCLC	USF2 →	-0.984	-0.526	<.001	.001	3	1
LUNG_SCLC	AK1 →	-0.789	-0.505	.001	<.001	3	1
LUNG_SCLC	SCP2 →	-0.917	-0.505	.001	<.001	3	1
LUNG_SCLC	RPS6KA1 →	-1.155	-0.483	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051295 vs SPECC1L — LUNG_SCLC

Explore this scatter interactively →