Establishment of meiotic spindle localization

Across TCGA cell cohorts, RNA activity of the Establishment of meiotic spindle localization pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Gefitinib, XAV939, and Dyrk1b_0191, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Gefitinib grouped by Establishment of meiotic spindle localization-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Gefitinib →	+0.468	+0.547	.025	<.001	3	1
LUNG_SCLC	XAV939 →	+0.816	+0.689	.041	<.001	3	1
LUNG_SCLC	Dyrk1b_0191 →	+0.393	+0.411	.012	.032	3	1
LUNG_SCLC	Ruxolitinib →	+0.836	+0.689	.043	<.001	3	1
LUNG_SCLC	EPZ5676 →	+0.666	+0.582	.049	.021	3	1
LUNG_SCLC	IWP-2 →	+0.556	+0.689	.029	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Gefitinib by Establishment of meiotic spindle localization activity — LUNG_SCLC

Explore this box plot interactively →