Nuclear pore complex assembly

Across TCGA cell cohorts, RNA activity of the Nuclear pore complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBX1, AKR1C3, and PPP1R12B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PBX1 grouped by Nuclear pore complex assembly-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PBX1 →	+2.841	+0.141	<.001	.002	3	3
PANCREAS	AKR1C3 →	+4.156	+0.108	.001	.006	3	3
PANCREAS	PPP1R12B →	+0.849	+0.110	.004	.004	3	3
OESOPHAGUS	DBR1 →	+0.717	+0.102	.006	.001	3	3
OESOPHAGUS	ASTE1 →	+0.604	+0.122	.004	.003	3	3
OVARY	SLCO4A1 →	-2.145	-0.129	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PBX1 by Nuclear pore complex assembly activity — PANCREAS

Explore this box plot interactively →