Nuclear pore complex assembly

Across TCGA cell cohorts, RNA activity of the Nuclear pore complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP251, ODF2, and POLE4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear pore complex assembly activity versus CFAP251 in STOMACH (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CFAP251 →	+1.359	+0.282	.008	.005	3	7
PANCREAS	ODF2 →	+1.065	+0.200	.002	.001	3	5
OVARY	POLE4 →	-0.976	-0.226	.003	.001	3	5
BREAST	DCAF15 →	+0.586	+0.196	.004	<.001	3	5
PANCREAS	CDCA8 →	+0.738	+0.178	.009	.005	3	5
KIDNEY	NUP107 →	+0.775	+0.197	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051292 vs CFAP251 — STOMACH

Explore this scatter interactively →