Protein heterooligomerization

Across TCGA patient cohorts, RNA activity of the Protein heterooligomerization pathway is significantly associated with the RNA expression of multiple genes, with the KIRC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS53, GTF2IP23, and PKD1P6, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterooligomerization activity versus PRSS53 in KIRC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	PRSS53 →	+0.897	+0.043	<.001	<.001	3	32
TGCT	GTF2IP23 →	+1.517	+0.038	<.001	<.001	3	32
UCS	PKD1P6 →	+1.222	+0.056	<.001	<.001	3	31
UCS	CICP14 →	+1.420	+0.046	<.001	<.001	3	31
UCS	PKD1 →	+1.042	+0.056	<.001	<.001	3	31
SCLC	TAS2R5 →	+0.980	+0.064	.003	<.001	2	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051291 vs PRSS53 — KIRC

Explore this scatter interactively →