Protein heterooligomerization

Across TCGA patient cohorts, RNA activity of the Protein heterooligomerization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESCO2, RRM2, and CDCA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterooligomerization activity versus ESCO2 in PDAC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ESCO2 →	+0.535	+0.154	<.001	<.001	3	6
LUAD	RRM2 →	+0.913	+0.203	<.001	<.001	3	5
LUAD	CDCA8 →	+0.666	+0.174	<.001	<.001	3	5
LUAD	SELENOI →	+0.523	+0.218	<.001	<.001	3	5
LUAD	FAM180A →	-0.607	-0.219	<.001	<.001	3	5
UCEC	DHRS12 →	-0.567	-0.172	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051291 vs ESCO2 — PDAC

Explore this scatter interactively →