Protein heterooligomerization

Across TCGA cell cohorts, RNA activity of the Protein heterooligomerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F2, KAT2A, and ANKRD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterooligomerization activity versus E2F2 in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	E2F2 →	+1.363	+0.184	<.001	<.001	3	5
PANCREAS	KAT2A →	+0.922	+0.227	<.001	<.001	3	5
PANCREAS	ANKRD1 →	-3.491	-0.164	.001	.003	3	5
PANCREAS	ZNF77 →	+0.604	+0.247	<.001	.001	3	5
BREAST	DUS3L →	+0.606	+0.166	.005	.008	3	5
BREAST	FNDC8 →	+0.052	+0.195	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051291 vs E2F2 — BLOOD_Leukemia

Explore this scatter interactively →