Protein heterotetramerization

Across TCGA patient cohorts, RNA activity of the Protein heterotetramerization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBK, ESCO2, and UBE2T, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein heterotetramerization activity versus PBK in LUAD (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PBK →	+1.231	+0.247	<.001	<.001	3	8
LUAD	ESCO2 →	+0.691	+0.232	<.001	<.001	3	8
LUAD	UBE2T →	+0.940	+0.184	<.001	<.001	3	8
LUAD	DDIAS →	+0.774	+0.218	<.001	<.001	3	8
LUAD	SPAG5 →	+0.901	+0.156	<.001	<.001	3	8
LUAD	DNA2 →	+0.512	+0.167	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051290 vs PBK — LUAD

Explore this scatter interactively →