Positive regulation of release of sequestered calcium ion into cytosol

Across TCGA patient cohorts, RNA activity of the Positive regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WARS1, GBP4, and STAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of release of sequestered calcium ion into cytosol activity versus WARS1 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WARS1 →	+0.649	+0.063	<.001	.001	3	9
UCEC	GBP4 →	+0.678	+0.065	<.001	<.001	3	9
HNSC	STAT1 →	+0.587	+0.053	<.001	<.001	3	8
COAD	FCER1G →	+0.740	+0.027	<.001	<.001	3	8
BRCA	GBP1 →	+0.738	+0.038	<.001	<.001	3	8
UCEC	LCP2 →	+0.457	+0.058	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051281 vs WARS1 — UCEC

Explore this scatter interactively →