Positive regulation of release of sequestered calcium ion into cytosol

Across TCGA cell cohorts, RNA activity of the Positive regulation of release of sequestered calcium ion into cytosol pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTO1, NR4A2, and TBRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of release of sequestered calcium ion into cytosol activity versus GSTO1 in LUNG_NSCLC_LUAD (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GSTO1 →	+0.810	+0.392	<.001	<.001	3	5
STOMACH	NR4A2 →	+1.780	+0.551	.002	.003	3	5
CNS	TBRG1 →	+0.726	+0.589	.002	.008	3	4
BLOOD_Lymphoma	YES1 →	+1.333	+0.239	.003	.001	3	4
BREAST	RRP9 →	+0.623	+0.726	.003	.001	3	4
BLOOD_Lymphoma	CISH →	+3.445	+0.334	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051281 vs GSTO1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →