Protein tetramerization

Across TCGA patient cohorts, RNA activity of the Protein tetramerization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLR2, ZRANB2_S188, and GIMAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein tetramerization activity versus TLR2 in COAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLR2 →	+0.621	+0.022	<.001	<.001	3	4
PDAC	ZRANB2_S188 →	-0.493	-0.018	<.001	<.001	3	4
OV	GIMAP1 →	+0.418	+0.023	<.001	.001	3	4
PDAC	LAD1 →	-0.316	-0.027	.003	<.001	3	4
PDAC	OCIAD1_S108 →	+0.862	+0.029	.004	.001	3	4
PDAC	PTPRC →	+0.523	+0.024	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051262 vs TLR2 — COAD

Explore this scatter interactively →