Protein tetramerization

Across TCGA cell cohorts, RNA activity of the Protein tetramerization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB9, TAP1, and HLA-C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein tetramerization activity versus PSMB9 in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PSMB9 →	+4.040	+0.292	<.001	<.001	3	5
BONE	TAP1 →	+2.959	+0.288	<.001	.001	3	5
BONE	HLA-C →	+3.021	+0.310	.001	<.001	3	5
BONE	HLA-A →	+1.963	+0.310	.001	<.001	3	5
KIDNEY	DCAF11 →	+0.708	+0.255	.003	.004	3	4
KIDNEY	ERO1A →	+1.202	+0.267	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051262 vs PSMB9 — BONE

Explore this scatter interactively →