Protein depolymerization

Across TCGA cell cohorts, RNA activity of the Protein depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRK4, AZIN2, and FAM229A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRK4 grouped by Protein depolymerization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GRK4 →	-0.712	-0.291	.001	.008	3	5
LARGE_INTESTINE	AZIN2 →	-1.361	-0.238	.001	.001	3	5
LUNG_NSCLC_LUSC	FAM229A →	-1.449	-0.372	<.001	.004	3	4
KIDNEY	NSUN2 →	+0.642	+0.232	.002	.003	3	4
LUNG_NSCLC_LUSC	THAP3 →	-0.657	-0.273	.004	.003	3	4
OESOPHAGUS	MAP1B →	-2.107	-0.205	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRK4 by Protein depolymerization activity — BLOOD_Myeloma

Explore this box plot interactively →