Protein homooligomerization

Across TCGA patient cohorts, RNA activity of the Protein homooligomerization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP1, GBP1, and AMPD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein homooligomerization activity versus LCP1 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP1 →	+0.813	+0.034	<.001	<.001	3	8
LUAD	GBP1 →	+0.548	+0.018	<.001	<.001	3	7
GBM	AMPD3 →	+0.446	+0.020	<.001	<.001	3	7
GBM	NCF4 →	+0.637	+0.030	<.001	<.001	3	7
GBM	ARHGAP45 →	+0.403	+0.022	<.001	<.001	3	7
CCRCC	LPXN →	+0.531	+0.035	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051260 vs LCP1 — GBM

Explore this scatter interactively →