Protein homooligomerization

Across TCGA patient cohorts, RNA activity of the Protein homooligomerization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP55, TRMU, and DERL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein homooligomerization activity versus CEP55 in OV (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CEP55 →	+0.634	+0.092	.006	.004	3	4
OV	TRMU →	+0.499	+0.146	.002	.001	3	3
PDAC	DERL1 →	+0.325	+0.165	.002	.004	3	3
PDAC	MYO7A →	+0.259	+0.124	.008	.009	3	3
HNSC	SPOUT1 →	+0.267	+0.162	.001	.001	3	3
OV	SLC12A5 →	+0.151	+0.115	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051260 vs CEP55 — OV

Explore this scatter interactively →