Protein homooligomerization

Across TCGA cell cohorts, RNA activity of the Protein homooligomerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB27A, POC1A, and SPCS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB27A grouped by Protein homooligomerization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAB27A →	-0.764	-0.093	.006	<.001	3	6
LUNG_SCLC	POC1A →	-0.998	-0.181	.001	.001	3	5
BONE	SPCS1 →	-0.815	-0.185	.004	.002	3	4
BLOOD_Myeloma	DCTN6 →	+1.179	+0.123	.004	.004	3	4
LUNG_NSCLC_LUSC	LRP5 →	+1.064	+0.139	.003	.009	3	4
PANCREAS	IRX3 →	-2.332	-0.154	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB27A by Protein homooligomerization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →