Protein complex oligomerization

Across TCGA patient cohorts, RNA activity of the Protein complex oligomerization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP1, ARRB2, and CORO1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein complex oligomerization activity versus LCP1 in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP1 →	+0.748	+0.021	<.001	<.001	3	9
GBM	ARRB2 →	+0.187	+0.020	.002	<.001	3	8
GBM	CORO1A →	+0.547	+0.026	<.001	<.001	3	8
GBM	LCP2 →	+0.440	+0.024	<.001	<.001	3	8
GBM	MYO1F →	+0.598	+0.029	<.001	<.001	3	8
GBM	ARHGAP45 →	+0.481	+0.024	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051259 vs LCP1 — GBM

Explore this scatter interactively →