Protein complex oligomerization

Across TCGA cell cohorts, RNA activity of the Protein complex oligomerization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POC1A, KLHL6, and TMEM74B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POC1A grouped by Protein complex oligomerization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	POC1A →	-1.047	-0.176	.004	.009	3	4
SOFT_TISSUE	KLHL6 →	+0.020	+0.140	.005	.002	3	4
LARGE_INTESTINE	TMEM74B →	+1.444	+0.145	.005	.008	3	4
LARGE_INTESTINE	ZC3H12D →	+0.642	+0.108	.002	.002	3	4
BONE	ATG9B →	+1.642	+0.126	.007	.004	2	5
LIVER	CRTAP →	-1.654	-0.172	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POC1A by Protein complex oligomerization activity — BONE

Explore this box plot interactively →