Protein complex oligomerization

Across TCGA cell cohorts, RNA activity of the Protein complex oligomerization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEAK7, RRAS2, and C20orf96, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein complex oligomerization activity versus MEAK7 in OVARY (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MEAK7 →	+1.043	+0.150	<.001	<.001	3	5
OVARY	RRAS2 →	+1.099	+0.162	.002	.002	3	5
LIVER	C20orf96 →	-1.212	-0.210	.001	.001	3	4
STOMACH	LRRC59 →	+1.261	+0.144	.006	.006	2	5
OVARY	NCEH1 →	+1.809	+0.147	<.001	<.001	3	4
BLOOD_Leukemia	TTC39C →	+1.390	+0.120	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051259 vs MEAK7 — OVARY

Explore this scatter interactively →