Protein polymerization

Across TCGA patient cohorts, RNA activity of the Protein polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, QKI, and YME1L1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polymerization activity versus MAP1B in CCRCC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MAP1B →	+0.450	+0.022	.002	<.001	3	8
BRCA	QKI →	+0.298	+0.018	<.001	<.001	3	8
OV	YME1L1 →	-0.254	-0.038	.004	<.001	3	7
BRCA	TIMP2 →	+0.663	+0.018	.008	<.001	3	7
GBM	SYNPO →	+0.443	+0.047	<.001	<.001	3	7
LSCC	STAB1 →	+0.235	+0.025	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051258 vs MAP1B — CCRCC

Explore this scatter interactively →