Protein polymerization

Across TCGA cell cohorts, RNA activity of the Protein polymerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLST, RAB24, and RPS24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLST grouped by Protein polymerization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DLST →	-1.001	-0.352	.001	<.001	3	5
PANCREAS	RAB24 →	-0.794	-0.135	<.001	.002	3	4
BREAST	RPS24 →	-0.690	-0.116	.009	.008	3	4
STOMACH	DUSP10 →	+2.178	+0.181	.009	.008	2	5
LARGE_INTESTINE	GIMAP2 →	+1.420	+0.159	.005	.003	3	4
BLOOD_Lymphoma	HPS1 →	-0.947	-0.233	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLST by Protein polymerization activity — BLOOD_Myeloma

Explore this box plot interactively →