Protein polymerization

Across TCGA cell cohorts, RNA activity of the Protein polymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM214A, ZDHHC18, and HSPB11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein polymerization activity versus FAM214A in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM214A →	+1.287	+0.177	.001	.001	3	5
BLOOD_Leukemia	ZDHHC18 →	+0.663	+0.163	<.001	.002	3	4
PANCREAS	HSPB11 →	+0.629	+0.194	.008	.005	3	4
LIVER	RGS12 →	+1.230	+0.235	.001	<.001	3	4
LIVER	VWA7 →	+1.598	+0.207	.002	.009	3	4
STOMACH	AKT1 →	+0.785	+0.226	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051258 vs FAM214A — LUNG_NSCLC_LUAD

Explore this scatter interactively →