Spindle midzone assembly

Across TCGA patient cohorts, RNA activity of the Spindle midzone assembly pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN_S485, MCM6, and LIG1_T183, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle midzone assembly activity versus ANLN_S485 in CCRCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANLN_S485 →	+1.504	+0.182	.006	<.001	3	9
LUAD	MCM6 →	+0.834	+0.195	<.001	<.001	3	9
LUAD	LIG1_T183 →	+1.114	+0.197	<.001	<.001	3	8
LUAD	TACC3_S71 →	+1.118	+0.155	<.001	<.001	3	8
LUAD	UFD1_S247 →	+0.872	+0.187	<.001	<.001	3	8
CCRCC	USP34_T3350 →	+1.267	+0.262	.004	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051255 vs ANLN_S485 — CCRCC

Explore this scatter interactively →