Spindle midzone assembly

Across TCGA patient cohorts, RNA activity of the Spindle midzone assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, GINS1, and MYBL2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spindle midzone assembly activity versus NUF2 in BRCA (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	+1.301	+0.521	<.001	<.001	3	9
GBM	GINS1 →	+0.839	+0.517	<.001	<.001	3	8
BRCA	MYBL2 →	+1.272	+0.368	<.001	<.001	3	8
BRCA	E2F1 →	+1.008	+0.389	<.001	<.001	3	8
BRCA	FAM83D →	+1.196	+0.522	<.001	<.001	3	8
LSCC	CENPI →	+1.195	+0.622	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051255 vs NUF2 — BRCA

Explore this scatter interactively →